Ball July 10, - April 12, , an ad executive, was the person with the strongest claim to having invented the smiley face -- the simple, circular yellow face with an ear-to-ear grin and no ears. Ball founded an advertising and PR agency in Worcester, Massachusetts. In , one of his clients, State Mutual Life Assurance Company of America, asked him to help with the reassurance of workers in the wake of a merger. It stands to reason: At least he wasn't fined.
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AIDS ref , corticosteroid overdosage, chronic liver disease ref1 , ref2 and inflammatory bowel disease ref post-surgical conditions nutritional deprivation e. Data from in vitro studies and animal models suggest that increased levels of inflammatory cytokines can induce cachexia and might inhibit the effects of GH on target tissues. The molecular mechanisms involved are unclear, although an effect of cytokines on GH receptor signalling has been suggested. The GH-activated pathways that mediate the increase in IGF-I levels are not well understood, thereby impeding the elucidation of the effect of inflammatory cytokines. This is initially due to a transient GH resistance, but in the longer term, the less pulsatile pattern of GH secretion may be a major factor since only pulsatile growth hormone increases the levels of IGF-I and the acid-labile subunit. Other factors contributing to a low IGF level are nutritional deficiency and the direct effects of inflammatory cytokines. IGFBP-1, which is acutely regulated by metabolic status, is elevated on admission to intensive care but may fall in response to nutritional support.
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The nephron The kidneys transport substances by three vectorial processes. Vectorial processes are characterized by their direction and size only Fig. Black arrows indicate three vectorial transporting processes in a nephron: Tubular reabsorption is the net movement of water and solute from the tubular lumen to the tubule cells and to the peritubular capillaries, and 3. Tubular secretion represents the net addition of solute to the tubular fluid.